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Agaricus Blazei Murrill

  1. Fujimiya Y, Suzuki Y, Oshiman K, et al. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Cancer Immunol Immunother. May 1998;46(3):147-159.
  2. Itoh H, Ito H, Amano H, et al. Inhibitory action of a (1—>6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill (“himematsutake”) on Meth A fibrosarcoma-bearing mice and its antitumor mechanism. Jpn J Pharmacol. Oct 1994;66(2):265-271.
  3. Kimura Y, Kido T, Takaku T, et al. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Sci. Sep 2004;95(9):758-764.
  4. Lee YL, Kim HJ, Lee MS, et al. Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model. Exp Anim. Oct 2003;52(5):371-375.
  5. Mizuno M, Morimoto M, Minato K, et al. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem. Mar 1998;62(3):434-437.
  6. Takaku T, Kimura Y, Okuda H. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr. May 2001;131(5):1409-1413.
  7. Ahn WS, Kim DJ, Chae GT, et al. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer. Jul-Aug 2004;14(4):589-594.
  8. Gray AM, Flatt PR. Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom). J Endocrinol. May 1998;157(2):259-266.
  9. Swanston-Flatt SK, Day C, Flatt PR, et al. Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res. Feb 1989;10(2):69-73.
  10. Kim YW, Kim KH, Choi HJ, et al. Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei. Biotechnol Lett. Apr 2005;27(7):483-487.
  11. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. Jan-Feb 2007;13(1):97-102.
  12. Liu Y, Fukuwatari Y, Okumura K, et al. Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers. Evid Based Complement Alternat Med. Jun 2008;5(2):205-219.
  13. Hsu CH, Hwang KC, Chiang YH, et al. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med. Apr 2008;14(3):299-301.
  14. Mukai H, Watanabe T, Ando M, et al. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol. Dec 2006;36(12):808-810.
  15. Suehiro M, Katoh N, Kishimoto S. Cheilitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis. May 2007;56(5):293-294.
  16. Dong S, Furutani Y, Suto Y, et al. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract. Microbiol Res. Oct 17 2011.
  17. Takimoto H, Wakita D, Kawaguchi K, et al. Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies. Biol Pharm Bull. Mar 2004;27(3):404-406.
  18. Yuminamochi E, Koike T, Takeda K, et al. Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill. Immunology. Jun 2007;121(2):197-206.
  19. Gao L, Sun Y, Chen C, et al. Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ss prepared from the mushroom Agaricus blazei Murill. Braz J Med Biol Res. Nov 2007;40(11):1545-1555.
  20. Jin CY, Moon DO, Choi YH, et al. Bcl-2 and caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt. Biol Pharm Bull. Aug 2007;30(8):1432-1437.
  21. Su ZY, Tung YC, Hwang LS, et al. Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways. J Agric Food Chem. May 11 2011;59(9):5109-5116.
  22. Akiyama H, Endo M, Matsui T, et al. Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937. Biochim Biophysica Acta. May 2011;1810(5):519-525.
  23. Engdal S, Nilsen OG. In vitro inhibition of CYP3A4 by herbal remedies frequently used by cancer patients. Phytother Res. 2009 Jul;23(7):906-12.
  24. Lee JS, Hong EK. Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation.Int J Oncol. 2011 Feb;38(2):401-8.
  25. Lima CU, Souza VC, Morita MC, Chiarello MD, Karnikowski MG. Agaricus blazei Murrill and inflammatory mediators in elderly women: a randomized clinical trial. Scand J Immunol. 2012 Mar;75(3):336-41.
  26. Ohno S, Sumiyoshi Y, Hashine K, Shirato A, Kyo S, Inoue M. Quality of life improvements among cancer patients in remission following the consumption of Agaricus blazei Murill mushroom extract.Complement Ther Med. 2013 Oct;21(5):460-7.
  27. Dong S, Furutani Y, Kimura S, et al. Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia. J Agric Food Chem. 2013 Jan 9;61(1):128-36.
  28. Li X, Zhao X, Wang H, Han J, Liu L.A polysaccharide from the fruiting bodies of Agaricus blazei Murill induces caspase-dependent apoptosis in human leukemia HL-60 cells. Tumour Biol. 2014 Sep;35(9):8963-8.
  29. Tangen JM, Tierens A, Caers J, et al. Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study. Biomed Res Int. 2015;2015:718539.
  30. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. PLoS One. 2016 Mar 2;11(3):e0150191.

 


Ganoderma lucidum

  1. Huang K. The Pharmacology of Chinese Herbs. 2nd ed. New York: CRC Press; 1999.
  2. Chen HS, Tsai YF, Lin S, et al. Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharidesBioorg Med Chem. Nov 1 2004;12(21):5595-5601.
  3. Gao Y, Zhou S, Wen J, et al. Mechanism of the antiulcerogenic effect of Ganoderma lucidumpolysaccharides on indomethacin-induced lesions in the ratLife Sci. Dec 27 2002;72(6):731-745.
  4. Hsu MJ, Lee SS, Lin WW. Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathwayJ Leukoc Biol. Jul 2002;72(1):207-216.
  5. Wang SY, Hsu ML, Hsu HC, et al. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytesInt J Cancer. Mar 17 1997;70(6):699-705.
  6. Wachtel-Galor S, Szeto YT, Tomlinson B, et al. Ganoderma lucidum (’Lingzhi’); acute and short-term biomarker response to supplementationInt J Food Sci Nutr. Feb 2004;55(1):75-83.
  7. Wachtel-Galor S, Tomlinson B, Benzie IF. Ganoderma lucidum (“Lingzhi”), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation studyBr J Nutr. Feb 2004;91(2):263-269.
  8. Gao Y, Zhou S, Jiang W, et al. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patientsImmunol Invest. Aug 2003;32(3):201-215.
  9. Shieh YH, Liu CF, Huang YK, et al. Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice. Am J Chin Med. 2001;29(3-4):501-7.
  10. Noguchi M, Kakuma T, Tomiyasu K, et al. Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptomsAsian J Androl. Sep 2008;10(5):777-785.
  11. Hobbs C. Medicinal Mushrooms. 3rd ed. Loveland (OR): Interweave Press; 1996.
  12. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of Ganoderma lucidum on platelet aggregationJ Tongji Med Univ. 1990;10(4):240-243.
  13. Wang CZ, Basila D, Aung HH, et al. Effects of Ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat modelAm J Chin Med. 2005;33(5):807-815.
  14. Gill SK, Rieder MJ. Toxicity of a traditional Chinese medicine, Ganoderma lucidum, in children with cancer. Can J Clin Pharmacol. Summer 2008;15(2):e275-285.
  15. Wang X, Zhao X, Li D, et al. Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in ratsBiol Pharm Bull. Sep 2007;30(9):1702-1706.
  16. Chen NH, Liu JW, Zhong JJ. Ganoderic Acid me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expressionJ Pharmacol Sci. Oct 2008;108(2):212-216.
  17. Li YB, Wang R, Wu HL, et al. Serum amyloid A mediates the inhibitory effect of Ganoderma lucidumpolysaccharides on tumor cell adhesion to endothelial cellsOncol Rep. Sep 2008;20(3):549-556.
  18. Mao T, van De Water J, Keen CL, et al. Two mushrooms, Grifola frondosa and Ganoderma lucidum, can stimulate cytokine gene expression and proliferation in human T lymphocytes. Int J Immunother 1999;15(1):13-22.
  19. Chan WK, Cheung CC, Law HK, et al. Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory functionJ Hematol Oncol. 2008;1(1):9.
  20. Noguchi M, Kakuma T, Tomiyasu K, et al. Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study. Asian J Androl. 2008 Jul;10(4):651-8.
  21. Weng CJ, Yen GC. The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis. Clin Exp Metastasis. 2010 May;27(5):361-9.
  22. Kim KC, Jun HJ, Kim JS, Kim IG. Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells. Int J Mol Med. 2008 Apr;21(4):489-98.
  23. Gordan JD, Chay WY, Kelley RK, et al. “And what other medications are you taking?”. J Clin Oncol. 2011 Apr 10;29(11):e288-91.
  24. Yuen MF, Ip P, Ng WK, Lai CL. Hepatotoxicity due to a formulation of Ganoderma lucidum (lingzhi). J Hepatol. 2004 Oct;41(4):686-7.
  25. Wanmuang H, Leopairut J, Kositchaiwat C, Wananukul W, Bunyaratvej S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007 Jan;90(1):179-81.
  26. Wanachiwanawin D, Piankijagum A, Chaiprasert A, et al. Ganoderma lucidum: a cause of pseudoparasitosis. Southeast Asian J Trop Med Public Health. 2006 Nov;37(6):1099-102.
  27. Zhao S, Ye G, Fu G, Cheng JX, Yang BB, Peng C. Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. Int J Oncol. 2011 May;38(5):1319-27.
  28. Pillai TG, John M, Sara Thomas G. Prevention of cisplatin induced nephrotoxicity by terpenes isolated from Ganoderma lucidum occurring in Southern Parts of India. Exp Toxicol Pathol. 2011 Jan;63(1-2):157-60.
  29. Chu TT, Benzie IF, Lam CW, et al. Study of potential cardioprotective effects of Ganoderma lucidum(Lingzhi): results of a controlled human intervention trial. The British journal of nutrition. 2012 Apr;107(7):1017-27.
  30. Jin X, Ruiz Beguerie J, Sze DM, Chan GC . Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. 2012 Jun 13;6:CD007731.
  31. Chang CJ, Chen YY, Lu CC, et al. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immun. 2014 Apr;20(3):301-11.
  32. Sun LX, Lin ZB, Duan XS, et al. Enhanced MHC class I and costimulatory molecules on B16F10 cells by Ganoderma lucidum polysaccharides. J Drug Target.2012 Aug;20(7):582-92.
  33. Boh B, Berovic M, Zhang J, Zhi-Bin L. Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev. 2007;13:265-301.
  34. Paterson RR. Ganoderma – a therapeutic fungal biofactory. Phytochemistry. 2006 Sep;67(18):1985-2001.
  35. Liang Y, He M, Fan X, et al. An abnormal elevation of serum CA72-4 by Ganoderma lucidum spore powder. Ann Clin Lab Sci. 2013 Summer;43(3):337-40.
  36. Joseph S, Sabulal B, George V, Antony KR, Janardhanan KK. Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganodermalucidum. Acta Pharm. 2011 Sep 1;61(3):335-42.
  37. Jin H, Jin F, Jin JX, et al. Protective effects of Ganoderma lucidum spore on cadmium hepatotoxicity in mice. Food Chem Toxicol. 2013 Feb;52:171-5.
  38. Klupp NL, Chang D, Hawke F, et al. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015;2:CD007259.
  39. Ko KK, Murthee KG, Koh TH, et al. Reishi (lingzhi) ingestion mistaken for persistent Clonorchis infection. Pathology. Oct 2014;46(6):576-578.
  40. Sun LX, Li WD, Lin ZB, et al. Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides. Cell Physiol Biochem. 2014;33(2):289-299.
  41. Oka S, Tanaka S, Yoshida S, et al. A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Hiroshima J Med Sci. Mar 2010;59(1):1-6.
  42. Yan B, Meng X, Shi J, et al. Ganoderma lucidum spore induced CA72-4 elevation in gastrointestinal cancer: a five-case report. Integr Cancer Ther. Mar 2014;13(2):161-166.
  43. Klupp NL, Kiat H, Bensoussan A, et al. A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome. Sci Rep. Aug 11 2016;6:29540.
  44. Jin X, Ruiz Beguerie J, Sze DM, et al. Ganoderma lucidum (Reishi mushroom) for cancer treatment.Cochrane Database Syst Rev. Apr 05 2016;4:Cd007731.
  45. Santesso N, Wieland LS. A Summary of a Cochrane Review: Ganoderma lucidum (Reishi mushroom) for the treatment of cancer. Eur J Integr Med. Oct 2016;8(5):619-620.

 


Grifola frondosa

  1. Hobbs C. Medicinal Mushrooms, 3rd ed. Loveland (CO): Interweave Press; 1996.
  2. Adachi K, Nanba H, Kuroda H. Potentiation of host-mediated antitumor activity in mice by beta glucan obtained from Grifola frondosa (maitake). Chem Pharm Bull 1987;35:262-70.
  3. Kubo K, Aoki H. Nanba H. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). Biol Pharm Bull 1994;17:1106-10.
  4. Horio H, Ohtsuru M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol 2001;47:57-63.
  5. Kodama N, Komuta K, Nanba H. Can Maitake MD-fraction aid cancer patients? Altern Med Rev 2002;7:236-9.
  6. Miura NN. Blood clearance of (1—>3)-beta-D-glucan in MRL lpr/lpr mice. FEMS Immunol MedMicrobiol 1996;13:51-7.
  7. Ohno N, et al. Characterization of the antitumor glucan obtained from liquid-cultured Grifola frondosa. Chem Pharm Bull 1986;34:1709-1715.
  8. Nanba H, Kubo K. Maitake D-fraction: Healing and preventive potential for cancer. J Orthomolecular Med 1997;12:43-9.
  9. Konno S, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients.Diabet Med 2001 Dec;18(12):1010
  10. Yamada Y, et al. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790-6.
  11. Lin H, et al. Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro. Int Immunopharmacol 2004 Jan;4(1):91-9.
  12. Hong L, Xun M, Wutong W. Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice. Pharm Pharmacol. 2007 Apr;59(4):575-82.
  13. Masuda Y, Murata Y, Hayashi M, Nanba H. Inhibitory effect of MD-Fraction on tumor metastasis: involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung vascular endothelial cells. Biol Pharm Bull 2008 Jun;31(6):1104-8.
  14. Deng G, Lin H, Seidman A, et al. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol. 2009 Sep;135(9):1215-21
  15. Harada N, Kodama N, Nanba H. Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice. Cancer Lett. 2003;192(2):181-7.
  16. Shomori K, Yamamoto M, Arifuku I, Teramachi K, Ito H. Antitumor effects of a water-soluble extract from Maitake (Grifola frondosa) on human gastric cancer cell lines. Oncol Rep. 2009 Sep;22(3):615-20.
  17. Lin H, de Stanchina E, Zhou XK, et al. Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity. Cancer Immunol Immunother. 2010 Jun;59(6):885-97.
  18. Louie B, Rajamahanty S, Won J, Choudhury M, Konno S. Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells. BJU Int. 2010 Apr;105(7):1011-5.
  19. Lee JS, Park SY, Thapa D, et al. Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling. Exp Mol Med. 2010 Feb 28;42(2):143-54.
  20. Masuda Y, Ito K, Konishi M, Nanba H. A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. Cancer Immunol Immunother. 2010 Oct;59(10):1531-41.
  21. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother. 2010 Jan;44(1):223-4.
  22. Chen JT, Tominaga K, Sato Y, Anzai H, Matsuoka R. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Complement Med. 2010 Dec;16(12):1295-9.
  23. Soares R, Meireles M, Rocha A, et al. Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation.J Med Food. 2011 Jun;14(6):563-72.
  24. Fang J, Wang Y, Lv X, et al. Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling. Glycoconj J. 2012 Aug;29(5-6):365-77.
  25. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II studyCancer Immunol Immunother. (2015) 64:237–247 DOI 10.1007/s00262-014-1628-6

 


Shiitake

  1. Ng ML, Yap AT. Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes). J Altern Complement Med 2002;8(5):581-589.
  2. Okamoto T, Kodoi R, Nonaka Y, et al. Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver. Biofactors. 2004;21(1-4):407-409.
  3. Ngai PH, Ng TB. Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells. Life Sci. Nov 14 2003;73(26):3363-3374.
  4. Israilides C, Kletsas D, Arapoglou D, et al. In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes. Phytomedicine 2008.
  5. Akamatsu S, Watanabe A, Tamesada M, et al. Hepatoprotective effect of extracts from Lentinus edodes mycelia on dimethylnitrosamine-induced liver injury. Biol Pharm Bull. 2004;27(12):1957-1960.
  6. de Lima PL, Delmanto RD, Sugui MM, et al. Letinula edodes (Berk.) Pegler (Shiitake) modulates genotoxic and mutagenic effects induced by alkylating agents in vivo. Mutat Res. 2001;496(1-2):23-32.
  7. Shouji N, Takada K, Fukushima K, Hirasawa M. Anticaries effect of a component from shiitake (an edible mushroom). Caries Res 2000;34(1):94-98.
  8. deVere White RW, Hackman RM, Soares SE, Beckett LA, Sun B. Effects of a mushroom mycelium extract on the treatment of prostate cancer. Urology 2002;60(4):640-644.
  9. Gordon M, Bihari B, Goosby E, et al. A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: a phase I/II trialJ Med 1998;29(5-6):305-330.
  10. Suzuki K, Tanaka H, Sugawara H, et al. Chronic hypersensitivity pneumonitis induced by Shiitake mushroom spores associated with lung cancer. Intern Med 2001;40(11):1132-1135.
  11. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatology. 1998;197(3):255-257.
  12. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101(5):613-620.
  13. Hobbs C. Medicinal Mushrooms, 3rd ed. Loveland (CO): Interweave Press; 1996.
  14. Sia GM, Candish JK. Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line. Phytother Res 1999;13(2):133-7.
  15. Isoda N, Eguchi Y, Nukaya H, et al. Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma. Hepatogastroenterology. 2009 Mar-Apr;56(90):437-41.
  16. Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J. Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer. Anticancer Res. 2009 Jul;29(7):2739-45.
  17. Hazama S, Watanabe S, Ohashi M, et al. Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer. Anticancer Res. 2009 Jul;29(7):2611-7.
  18. Shimizu K, Watanabe S, Watanabe S, et al. Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer. Hepatogastroenterology. 2009 Jan-Feb;56(89):240-4.
  19. Garg S, Cockayne SE. Shiitake dermatitis diagnosed after 16 years! Arch Dermatol. 2008 Sep;144(9):1241-2.
  20. Goikoetxea MJ, Fernández-Benítez M, Sanz ML. Food allergy to Shiitake (Lentinus edodes) manifested as oesophageal symptoms in a patient with probable eosinophilic oesophagitis. Allergol Immunopathol (Madr). 2009 Nov-Dec;37(6):333-4.
  21. Yukawa H, Ishikawa S, Kawanishi T, Tamesada M, Tomi H. Direct cytotoxicity of Lentinula edodes mycelia extract on human hepatocellular carcinoma cell line. Biol Pharm Bull. 2012;35(7):1014-21.
  22. Okuno K, Uno K. Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study. Asian Pac J Cancer Prev. 2011;12(7):1671-4.
  23. Ampere A, Delhaes L, Soots J, Bart F, Wallaert B. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Med Mycol. 2012 Aug;50(6):654-7.
  24. Chu EY, Anand D, Dawn A, Elenitsas R, Adler DJ. Shiitake dermatitis: a report of 3 cases and review of the literature. Cutis. 2013 Jun;91(6):287-90.
  25. Adriano AR, Acosta ML, Azulay DR, et al. Shiitake dermatitis: the first case reported in Brazil. An Bras Dermatol. 2013 May-Jun;88(3):417-9.
  26. Hamer S, Rabindranathnambi R. A wide-spread flagellate dermatitis. BMJ Case Rep. 2013 Jan 3;2013.
  27. Wang AS, Barr KL, Jagdeo J. Shiitake mushroom-induced flagellate erythema: A striking case and review of the literature. Dermatol Online J. 2013 Apr 15;19(4):5.
  28. Kusumoto M, Koganemaru M, Nakayama G, Iwamoto R. Dietary small bowel obstruction. BMJ Case Rep. 2013 Jan 25;2013.
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Gránátalma kivonat

[1] Wang D, Özen C, Abu-Reidah IM,Chigurupati S, Patra JK,Horbanczuk JO, Jó ́zwik A,Tzvetkov NT, Uhrin P andAtanasov AG (2018) VasculoprotectiveEffects of Pomegranate (Punicagranatum L.).Front. Pharmacol. 9:544.doi: 10.3389/fphar.2018.00544.

[2] Waltenberger B, Mocan A, Šmejkal K, Heiss EH, Atanasov AG. Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders. Molecules. 2016 Jun 22;21(6). doi: 10.3390/molecules21060807.

[3] Gil MI, Tomás-Barberán FA, Hess-Pierce B, Holcroft DM, Kader AA. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 2000 Oct;48(10):4581-9. PubMed PMID: 11052704.

[4] Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis. 2001 Sep;158(1):195-8. PubMed PMID: 11500191.

[5] Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, Volkova N, Presser D, Attias J, Liker H, Hayek T. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004 Jun;23(3):423-33.

[6] Lynn A, Hamadeh H, Leung WC, Russell JM, Barker ME. Effects of pomegranate juice supplementation on pulse wave velocity and blood pressure in healthy young  and middle-aged men and women. Plant Foods Hum Nutr. 2012 Sep;67(3):309-14.

[7] Asgary S, Keshvari M, Sahebkar A, Hashemi M, Rafieian-Kopaei M. Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals. ARYA Atheroscler. 2013 Nov;9(6):326-31. PubMed PMID: 24575134; PubMed Central PMCID: PMC3933059.

[8] Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian-Kopaei M. Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects. Phytother Res. 2014 Feb;28(2):193-9. doi: 10.1002/ptr.4977.

[9] Sahebkar A, Ferri C, Giorgini P, Bo S, Nachtigal P, Grassi D. Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2017 Jan;115:149-161. doi: 10.1016/j.phrs.2016.11.018.

[10] Paller CJ, Ye X, Wozniak PJ, Gillespie BK, Sieber PR, Greengold RH, Stockton BR, Hertzman BL, Efros MD, Roper RP, Liker HR, Carducci MA. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis. 2013 Mar;16(1):50-5. doi: 10.1038/pcan.2012.20.

[11] Haghighian MK, Rafraf M, Moghaddam A, Hemmati S, Jafarabadi MA, Gargari BP. Pomegranate (Punica granatum L.) peel hydro alcoholic extract ameliorates cardiovascular risk factors in obese women with dyslipidemia: a double blind, randomized, placebo controlled pilot study. Eur J Integr Med. 2016; 8, 676–682. doi: 10.1016/j.eujim.2016.06.010.

[12] Sohrab G., Nasrollahzadeh J, Zand H, Amiri Z, Tohidi M, Kimiagar M: Effects of pomegranate juice consumption on inflammatory markers in patients with type 2 diabetes: A randomized, placebo-controlled trial.; J Res Med Sci.2014 Mar;19(3):215-20.

[13]  Mirmiran P, Fazeli MR, Asghari G, Shafiee A, Azizi F: Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial.; Br J Nutr. 2010 Aug;104(3):402-6. doi: 10.1017/S0007114510000504. Epub 2010 Mar 25.

[14] Esmaillzadeh A., Tahbaz F., Gaieni I., Alavi-Majd H., Azadbakht L.:Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia.; Int J Vitam Nutr Res. 2006 May;76(3):147-51.

[15] Al-Jarallah A, Igdoura F, Zhang Y, Tenedero CB, White EJ, MacDonald ME, Igdoura SA, Trigatti BL: Atherosclerosis. The effect of pomegranate extract on coronary artery atherosclerosis in SR-BI/APOE double knockout mice.; 2013 May;228(1):80-9. doi: 10.1016/j.atherosclerosis.2013.02.025. Epub 2013 Mar 7.

[16]  Kaplan M, Hayek T, Raz A, Coleman R, Dornfeld L, Vaya J, Aviram M: Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis.; J Nutr.2001 Aug;131(8):2082-9.

[17] Aviram M., Rosenblat M., Gaitini D., Nitecki S., Hoffman A.,Dornfeld L, Volkova N., Presser D., Attias J., Liker H., Hayek T.: Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.; Clin Nutr. 2004 Jun;23(3):423-33.

[18] Sedigheh Asgary, Amirhossein Sahebkar, Mohammad Reza Afshani, Mahtab Keshvari, Shaghayegh Haghjooyjavanmard, Mahmoud Rafieian‐Kopaei: Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti‐Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects; Phytotherapy Research, Volume28, Issue2, February 2014, Pages 193-199

[19] Sahebkar A, Ferri C, Giorgini P, Bo S, Nachtigal P, Grassi D5: Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials.; Pharmacol Res. 2017 Jan;115:149-161. doi: 10.1016/j.phrs.2016.11.018. Epub 2016 Nov 23.

*Dr. Dongdong Wang is affiliated with:

1) Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, ul. Postepu 36A, 05-552, Jastrzebiec, Poland.

2) Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria.

3) Institute of Clinical Chemistry, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland.

 


Süngomba (Hericium erinaceus)

[1] – Mori K1, Obara Y, Moriya T, Inatomi S, Nakahata N: Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.; Biomed Res. 2011 Feb;32(1):67-72

[2] – Tsai-Teng T, Chin-Chu C, Li-Ya L, Wan-Ping C, Chung-Kuang L, Chien-Chang S, Chi-Ying HF, Chien-Chih C, Shiao YJ: Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice.; J Biomed Sci. 2016 Jun 27;23(1):49. doi: 10.1186/s12929-016-0266-z.

[3] – Sheng X, Yan J, Meng Y, Kang Y, Han Z, Tai G, Zhou Y, Cheng H: Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology.; Food Funct. 2017 Mar 22;8(3):1020-1027. doi: 10.1039/c7fo00071e.

[4] – Diling C, Chaoqun Z, Jian Y, Jian L, Jiyan S, Yizhen X, Guoxiao L: Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota.; Front Immunol. 2017 Jun 12;8:666. doi: 10.3389/fimmu.2017.00666. eCollection 2017.

[5] – Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G: Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers.; J Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub 2014 Mar 12.

[6] – Sevcan Atay, Handan Ak, Erbil Kalmis, Husniye Kayalar, Hikmet Hakan Aydin: Transcriptome-Wide Analysis Reveals the Molecular Mechanism of Tumoricidal Effects of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), on MCF-7 Breast Cancer Cells; Int. J. of Medic. Mushrooms, Volume 23, Issue 1, 2021, pp. 91-106

[7] – Hou Y, Ding X, Hou W: Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus.; Mol Med Rep. 2015 May;11(5):3794-9. doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19.

[8] – Qin M, Geng Y, Lu Z, Xu H, Shi JS, Xu X, Xu ZH: Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis.; Int J Med Mushrooms. 2016;18(3):227-34. doi: 10.1615/IntJMedMushrooms.v18.i3.50.

[9] – Liu JH, Li L, Shang XD, Zhang JL, Tan Q.: Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2016 May 13;183:54-58. doi: 10.1016/j.jep.2015.09.004. Epub 2015 Sep 11

[10] – Hirokazu Kawagishi: Anti-MRSA Compounds from Hericium erinaceus (Bull.:Fr.) Pers.; International Journal of Medicinal Mushrooms 7(3):348-349 (2005)

[11] – Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS: Evaluation of the toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral feeding study in Sprague-Dawley rats.; Food Chem Toxicol. 2014 Aug;70:61-7. doi: 10.1016/j.fct.2014.04.040. Epub 2014 May 6.

 


Kínai hernyógomba (Cordyceps sinensis)

[1] – Yan JK, Li L, Wang ZM, Leung PH, Wang WQ, Wu JY. Acidic degradation and enhanced antioxidant activities of exopolysaccharides from Cordyceps sinensis mycelial culture. Food Chem. 2009; 117:641–6.

[2] – – Sheng L, Chen J, Li J, Zhang W. An exopolysaccharide from cultivated Cordyceps sinensis and its effects on citokine expressions of immunocytes. Appl Microbiol Biotechnol. 2011; 163:669–78

[3] – Kuo MC, Chang CY, Cheng TL, Wu MJ.: Immunomodulatory effect of exo-polysaccharides from submerged cultured Cordyceps sinensis: enhancement of citokine synthesis, CD11b expression, and phagocytosis. Appl Microbiol Biotechnol. 2007; 75:769–775.

[4] – Rao YK, Fang SH, Wu WS, Tzeng YM. Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator’s production and human cancer cell proliferation. J Ethnopharmacol. 2010; 131:363–367.

[5] – Yang ML, Kuo PC, Hwang TL, Wu TS. Anti-inflammatory principles from Cordyceps sinensis. J Nat Prod. 2011; 74:1996–2000.

[6] – Kiho T, Ookubo K, Usui S, Ukai S, Hirano K. Structural features and hypoglycemic activity of a polysaccharide (CS- F10) from the cultured mycelium of Cordyceps sinensis. Biol Pharm Bull. 1999; 22:966–70.

[7] – Kim SD. Isolation, structure and cholesterol esterase inhibitory activity of a polysaccharide, PS-A, from Cordyceps sinensis. J Appl Biol Chem. 2010; 53:784–9.

[8] – Anti-inflammation and antioxidant effect of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.

[9] – Song J,Wang Y,Teng M, Cai G, Xu H, Guo H, Liu Y, Wang D, Teng L. (2015): Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence Based Complimentary Alternative Medicine.

[10] – Siu KM, Mak DH, Chiu PY, Poon MK, Du Y, Ko KM. Pharmacological basis of ‘Yin-nourishing’ and ‘Yang-invigorating’ actions of Cordyceps, a Chinese tonifying herb. Life Sci. 2004; 76:385–95.

[11] – Li Y, Chen GZ, Jiang DZ.: Effect of Cordyceps sinensis on erythropoiesis in mouse bone marrow; Chinese Med J. 1993; 106:313–316.

[12] – Liu WC, Chuang WL, Tsai ML, Hong JH, Mcbride WH, Chiang CS. Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia;  Exp Biol Med. 2008; 233:447–55.

[13] – Chen, S., Li, Z., Krochmal, R., Abrazado, M., Kim, W., & Cooper, C. B. (2010). Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 16(5), 585–90

[14] – Manabe N, Azuma Y, Sugimoto M, Uchio K, Miyamoto M, Taketomo N, Tsuchita H, Miyamoto H. Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism and blood flow in dietary hypoferric anaemic mice. Br J Nutr. 2000; 83:197–204

[15] – Colson SN, et al. Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation. J Strength Cond Res. (2005)

[16] – Nakamura K, Yamaguchi Y, Kagota S, Kwon YM, Shinozuka K, Kunitomo M.: Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of lewis lung carcinoma and B16 melanoma cells in syngeneic mice. Jpn J Pharmacol. 1999;79: 335–341.

[17] – – Zhang HW, Lin ZX, Tung YS, Kwan TH, Mok CK, Leung C, Chan LS.: Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease; Cochrane Database Syst Rev. 2014 Dec 18;(12):CD008353. doi: 10.1002/14651858.CD008353.pub2.

[18] – Wang Y, Yin H, Lv X, Gao H, Wang M. Protection of chronic renal failure by a polysaccharide from Cordyceps sinensis. Fitoterapia. 2010; 81:397–402.

[19] – Hattori M, Isomura S, Yokoyama E, Ujita M, Hara A. Extracellular trypsin-like protease produced by Cordyceps militaris. J Biosci Bioeng. 2005; 100:631–636

[20] – Ji DB, et al. Antiaging effect of Cordyceps sinensis extract. Phytother Res. (2009)

[21] – Chang Y, et al. Effect of Cordyceps militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats. Am J Chin Med. (2008).

[22] – Koh J.-H., Kim J.-M., Chang U.-J., Suh H.-J. Hypocholesterolemic effect of hot-water extract from mycelia of Cordyceps sinensis; Biological and Pharmaceutical Bulletin. 2003;26(1):84–87. doi: 10.1248/bpb.26.84

[23] – Hsu C.-H., Sun H.-L., Sheu J.-N., et al. Effects of the immunomodulatory agent Cordyceps militaris on airway inflammation in a mouse asthma model. Pediatrics and Neonatology. 2008;49(5):171–178. doi: 10.1016/s1875-9572(09)60004-8.

[24] – Kuo Y.-C., Tsai W.-J., Wang J.-Y., Chang S.-C., Lin C.-Y., Shiao M.-S. Regulation of bronchoalveolar lavage fluids cell function by the immunomodulatory agents from Cordyceps sinensis . Life Sciences. 2001;68(9):1067–1082. doi: 10.1016/s0024-3205(00)01011-0.

[25] – Ningqun Wang, Jie Li, Xiaobo Huang, Wenqiang Chen, 1 and Yujing Chen: Herbal Medicine Cordyceps sinensis Improves Health-Related Quality of Life in Moderate-to-Severe Asthma; Evid Based Complement Alternat Med. 2016; 2016: 6134593

[26] – Chen S., Li Z., Krochmal R., Abrazado M., Kim W., Cooper C. B. Effect of Cs-4® (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine. 2010;16(5):585–590. doi: 10.1089/acm.2009.0226.

[27] – https://nephcure.org/wp-content/uploads/2019/01/Natural-Medicine-Kidney-Disease.pdf

[28] – Tingli Sun, Wenpeng Dong, Guohong Jiang, Jingbo Yang, Jizhang Liu, Lijie Zhao and Peilong Ma: Cordyceps militaris Improves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway; open access research article at Volume 2019 |Article ID 7850863 | https://doi.org/10.1155/2019/7850863

[29] – Kanitta Jiraungkoorskul and Wannee Jiraungkoorskul: Review of Naturopathy of Medical Mushroom, Ophiocordyceps Sinensis, in Sexual Dysfunction; Pharmacognosy Rev. 2016 Jan-Jun; 10(19): 1–5.

[30] – Hsu CC, Huang YL, Tsai SC, Sheu CC, Huang BM. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci. 2003;73:2127–36

[31] – Huang Y, Lu J, Zhu B, Wen Q, Jia F, Zeng S, et al. Prevention and improvement of adrenal glands and thymus hormones, and infertile sperm count improve by 300% after Cordyceps supplement. Zhong Cheng Yao Yan Jiu. 1987;10:24–5

 


Chaga (Inonotus obliquus)

[1] – Kim DH, Teng YC, Yoon YS, Qi XF, Jeong HS, Chang BS, Lee KJ.: The Anticancer Effect of Inonotus obliquus Pilat (Chaga) Processed by Nanomill Technology In Vivo; Korean Journal of Microscopy 2009 39 (2): 125-32

[2] – Shibnev V.A., Mishin D.V., Garaev T.M., Finogenova N.P., Botikov A.G., Deryabin P.G.: Antiviral activity of Inonotus obliquus fungus extract towards infection caused by hepatitis C virus in cell cultures; Bull. Exp. Biol. Med. 2011;151:612–614.

[3] – – Shibnev V.A., Garaev T.M., Finogenova M.P., Kalnina L.B., Nosik D.N.: Antiviral activity of aqueous extracts of the birch fungus Inonotus obliquus on the human immunodeficiency virus; Vopr. Virusol. 2015;60:35–38.

[4] – Zhang L, Fan C, Lui S, Zang Z, Jiao L, Zhang L.: Chemical Composition and Antitumor Activity of Polysaccharide from Inonotus obliquus; Journal of Medicinal Plants Research 2011 5 (7): 1251-1260.

[5] – Nomura M, Takahashi T, Uesugi A, Tanaka R, Kobayashi S.: Inotodiol, a Lanostane Triterpenoid, from Inonotus obliquus Inhibits Cell Proliferation through Caspase-3-dependent Apoptózis.; Anticancer Research 2008 28 (5A): 2691-2696

[6] – Park YK, Lee HB, Jeon EJ, Jung HS, Kang MH.: Chaga Mushroom Extract Inhibits Oxidative DNA Damage in Human Lymphocytes as Assessed by Comet Assay; BioFactors 2004 21: 109–112

[7] – Cui Y., Kim D.S., Park K.C.: Antioxidant effect of Inonotus obliquus.; J Ethnopharmacol. 2005 Jan 4;96(1-2):79-85.

[8] – Y.-M. Park, J.-H. Won, Y.-H. Kim, J.-W. Choi, H.-J. Park, and K.-T. Lee: In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus; Journal of Ethnopharmacology, vol. 101, no. 1–3, pp. 120–128, 2005.

[9] – Sun JE, Ao ZH, Lu ZM, Xu HY, Zhang XM, Dou WF, Xu ZH.: Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice; J Ethnopharmacol., 2008 Jun 19;118(1):7-13. doi: 10.1016/j.jep.2008.02.030. Epub 2008 Mar 4.

[10] – Hyun KW, Jeong SC, Lee DH, Park JS, Lee JS.: Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus; Peptides. 2006 Jun;27(6):1173-8. Epub 2005 Nov 11.

[11] – Wang C., Chen Z., Pan Y., Gao X. and Chen H.: Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice.; Food Chem Toxicol., 2017 Oct;108(Pt B):498-509. doi: 10.1016/j.fct.2017.01.007. Epub 2017 Jan 11.

[12] – Dosychev EA Prof., Bystrova VN.: Treatment of Psoriasis with Chaga Fungus Preparations; Vestnik Dermatologii I Venerologii 47 (5): 79-83

[13] – Zhong Xiuhong,  Zhong Yue, Yang Shuyan and Zheng Zhonghua: Effect of Inonotus Obliquus Polysaccharides on physical fatigue in mice – Experimental Study; Journal of Traditional Chinese Medicine, volume 35, Issue 4, 15 August 2015, pages 468-472

 

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